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Computational Pathology Detection of Hypoxia-Induced Morphological Changes in Breast Cancer.
Am J Pathol
December 2024
Department of Computer Science, Faculty of Engineering Sciences, University College London, Gower Street, London, WC1E 6BT, United Kingdom.
Understanding the tumor hypoxic microenvironment is crucial for grasping tumor biology, clinical progression, and treatment responses. This study presents a novel application of AI in computational histopathology to evaluate hypoxia in breast cancer. Weakly Supervised Deep Learning (WSDL) models can accurately detect morphological changes associated with hypoxia in routine Hematoxylin and Eosin (H&E) whole slide images (WSI).
View Article and Find Full Text PDFOcular Toxoplasmosis: Advances in Biology, Clinical Manifestations, Diagnostics, and Therapy.
Pathogens
October 2024
Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
, an obligate intracellular parasite, is a globally prevalent pathogen capable of infecting a wide range of warm-blooded animals, including humans. Ocular toxoplasmosis (OT), a severe manifestation of infection, can lead to potentially blinding complications. This comprehensive review delves into the current understanding of biology, exploring its complex life cycle, diverse transmission routes, and strain diversity.
View Article and Find Full Text PDFClinical Implication of Time of Ischaemic Stroke Among Post-Stroke Survivors from Eastern India: A Circadian Perspective.
Neuromolecular Med
October 2024
Molecular Biology & Clinical Neuroscience Division, National Neurosciences Centre, Calcutta, Peerless Hospital (2nd floor), 360, Panchasayar, Kolkata, 700094, India.
The circadian variation in stroke occurrence is a well-documented phenomenon. However, the circadian effect on stroke outcome, particularly on post-stroke cognition, has not yet been fully elucidated. We aim to evaluate the influence of diurnal variation of stroke onset upon post-stroke cognition and development of post-stroke depression.
View Article and Find Full Text PDFMolecular substratification of endometrial carcinomas with no special molecular profile (NSMP) by using a limited NGS custom panel may facilitate effective patient selection for the PIK3CA-targeted therapy.
Virchows Arch
September 2024
Department of Pathology, Medical Faculty in Pilsen, Charles University, Prague, Czech Republic.
Endometrial carcinomas (EC) of no special molecular profile (NSMP) represent the largest molecular category of EC, comprising a mixture of tumors with different histology and molecular profiles. These facts likely point to different tumor biology, clinical outcomes, and targeted therapy responses within this molecular category. The PIK3CA is currently the only targetable kinase oncoprotein directly implicated in EC carcinogenesis.
View Article and Find Full Text PDFThe third symposium on treatment-induced neuroendocrine prostate cancer: insights and future directions.
Epigenomics
October 2024
Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.
Article Synopsis
- - Neuroendocrine prostate cancer (NEPC) is an aggressive form of prostate cancer that arises after advanced treatments, marked by the loss of androgen receptor signaling and rapid progression.
- - The third symposium on NEPC, held in June 2024 in Canada, brought together leading researchers and clinicians to discuss recent advancements, molecular pathways, and innovative treatment strategies.
- - Experts emphasized the need for early detection and personalized medicine to tackle NEPC, highlighting the importance of global collaboration to improve understanding and treatment of this complex disease.
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