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High interest in preexposure prophylaxis among men who have sex with men at risk for HIV infection: baseline data from the US PrEP demonstration project. | LitMetric

High interest in preexposure prophylaxis among men who have sex with men at risk for HIV infection: baseline data from the US PrEP demonstration project.

J Acquir Immune Defic Syndr

*San Francisco Department of Public Health, San Francisco, CA; †Department of Medicine, University of California-San Francisco, San Francisco, CA; ‡Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL; §DF/Net Research, Inc, Seattle, WA; ‖Whitman-Walker Health Center, Washington, DC; and ¶Division of AIDS, National Institutes of Health, Bethesda, MD.

Published: April 2015

AI Article Synopsis

  • The study evaluates the interest and characteristics of men who have sex with men (MSM) and transgender women regarding PrEP, a medication to prevent HIV, in real-world clinical settings in the US.
  • Out of 1069 clients assessed at various clinics, 557 (60.5%) enrolled in the study, with higher enrollment rates seen among self-referred individuals, those aware of PrEP, and those with recent high-risk sexual behaviors.
  • The findings indicate that there is a significant interest in PrEP among MSM at risk for HIV when it is provided in sexual health clinics, highlighting its potential as an effective preventive measure.

Article Abstract

Background: Preexposure prophylaxis (PrEP) is the first biomedical intervention with proven efficacy to reduce HIV acquisition in men who have sex with men (MSM) and transgender women. Little is known about levels of interest and characteristics of individuals who elect to take PrEP in real-world clinical settings.

Methods: The US PrEP Demonstration Project is a prospective open-label cohort study assessing PrEP delivery in municipal sexually transmitted disease clinics in San Francisco and Miami and a community health center in Washington, DC. HIV-uninfected MSM and transgender women seeking sexual health services at participating clinics were assessed for eligibility and offered up to 48 weeks of emtricitabine/tenofovir for PrEP. Predictors of enrollment were assessed using a multivariable Poisson regression model, and characteristics of enrolled participants are described.

Results: Of 1069 clients assessed for participation, 921 were potentially eligible and 557 (60.5%) enrolled. In multivariable analyses, participants from Miami (adjusted Relative Risk [aRR]: 1.53; 95% confidence interval [CI]: 1.33 to 1.75) or DC (aRR: 1.33; 95% CI: 1.2 to 1.47), those who were self-referred (aRR: 1.48; 95% CI: 1.32 to 1.66), those with previous PrEP awareness (aRR: 1.56; 95% CI: 1.05 to 2.33), and those reporting >1 episode of anal sex with an HIV-infected partner in the last 12 months (aRR: 1.20; 95% CI: 1.09 to 1.33) were more likely to enroll. Almost all (98%) enrolled participants were MSM, and at baseline, 63.5% reported condomless receptive anal sex in the previous 3 months.

Conclusions: Interest in PrEP is high among a diverse population of MSM at risk for HIV infection when offered in sexually transmitted disease and community health clinics.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334721PMC
http://dx.doi.org/10.1097/QAI.0000000000000479DOI Listing

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