AI Article Synopsis

  • Young airway smooth muscle (ASM) is typically hyperresponsive, but this responsiveness decreases as individuals mature into adulthood.
  • The study tested whether neonatal allergic sensitization, specifically to ovalbumin in guinea pigs, could prevent this decline in responsiveness when there are no later allergen challenges.
  • Results showed that while neonatal sensitization did not affect ASM force generation, it did maintain a heightened ability for shortening velocity and resistance, indicating that early-life sensitization preserves the hyperresponsive ASM phenotype into adulthood.

Article Abstract

Airway smooth muscle (ASM) displays a hyperresponsive phenotype at young age and becomes less responsive in adulthood. We hypothesized that allergic sensitization, which causes ASM hyperresponsiveness and typically occurs early in life, prevents the ontogenetic loss of the ASM hyperresponsive phenotype. We therefore studied whether neonatal allergic sensitization, not followed by later allergen challenges, alters the ontogenesis of ASM properties. We neonatally sensitized guinea pigs to ovalbumin and studied them at 1 week, 3 weeks, and 3 months (adult). A Schultz-Dale response in isolated tracheal rings confirmed sensitization. The occurrence of inflammation was evaluated in the blood and in the submucosa of large airways. We assessed ASM function in tracheal strips as ability to produce force and shortening. ASM content of vimentin was also studied. A Schultz-Dale response was observed in all 3-week or older sensitized animals. A mild inflammatory process was characterized by eosinophilia in the blood and in the airway submucosa. Early life sensitization had no effect on ASM force generation, but prevented the ontogenetic decline of shortening velocity and the increase in resistance to shortening. Vimentin increased with age in control but not in sensitized animals. Allergic sensitization at birth without subsequent allergen exposures is sufficient to prevent normal ASM ontogenesis, inducing persistence to adulthood of an ASM hyperresponsive phenotype.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332219PMC
http://dx.doi.org/10.14814/phy2.12241DOI Listing

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