AI Article Synopsis
- A 37-year-old pregnant woman with a history of paroxysmal nocturnal hemoglobinuria (PNH) was treated with eculizumab, which successfully managed her condition without hemolytic attacks since starting the treatment at age 35.
- During her pregnancy, she continued eculizumab with no complications or exacerbation of hemolysis, leading to a successful Caesarean delivery of a healthy girl at 37 weeks and 3 days.
- Post-delivery, she received anticoagulant therapy and experienced mild hemolysis without thrombotic symptoms; both eculizumab and signs of hemolysis blockage were detected in the cord blood and breast milk.
Article Abstract
We report a 37-year-old pregnant woman with paroxysmal nocturnal hemoglobinuria (PNH) treated with eculizumab. She had been diagnosed with PNH-aplastic anemia at age 19 years, and started to receive eculizumab at age 35 years. Thereafter, she had no hemolytic attacks. She became pregnant 2 years later, and treatment with eculizumab was continued. During her pregnancy, she showed no exacerbation of hemolysis. She delivered a girl by Caesarean section at 37 weeks and 3 days of gestation. Postpartum, anticoagulant therapy was started. Although mild hemolysis and a rise in FDP/Ddimer were seen, she had no symptoms of thrombosis. Ten days after delivery, she and her baby were discharged. Eculizumab was present in the first breast milk and cord blood but was below detectable levels. The cord blood showed blockage of hemolysis.
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