AI Article Synopsis
- Aspirin is well-known for its anti-inflammatory benefits, making it useful as a pain reliever, fever reducer, and heart protection agent.
- Research shows that aspirin may also help prevent colorectal cancer by influencing Wnt signaling, which is crucial in cancer development.
- This review covers significant studies on how aspirin works against cancer and suggests ways to effectively implement these findings in medical practice.
Article Abstract
The anti-inflammatory properties of aspirin have resulted in its widespread use as an analgesic, antipyretic, and cardioprotective agent. Beyond these applications, multiple observational studies and randomized controlled trials have demonstrated a chemopreventative role for aspirin, particularly in the development of colorectal neoplasia. Given the critical importance of Wnt dysregulation in colorectal carcinogenesis, the interplay between aspirin and canonical Wnt signaling has become a focus of investigation. These studies have illuminated our understanding of the anticancer mechanisms of aspirin, yielding the identification of potential biomarkers for which aspirin's chemopreventative efficacy can be safely optimized into routine clinical practice and providing leads into the discovery of novel preventive and therapeutic targets. In this review, we summarize key experimental and clinical studies of this interaction, as well as highlighting future strategies to advance their clinical translation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383688 | PMC |
| http://dx.doi.org/10.1158/1078-0432.CCR-14-0877 | DOI Listing |
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