AI Article Synopsis
- * The MPN-BMSC exhibited increased levels of fibronectin, a protein involved in the extracellular matrix, which was confirmed by analysis of bone marrow biopsies from MPN patients.
- * Higher fibronectin levels were linked to lower hemoglobin levels in MPN patients, suggesting that measuring fibronectin could help identify early signs of a serious transformation in cases of MPN without typical fibrosis markers.
Article Abstract
We characterized bone marrow stromal cells (BMSC) from patients with pre-fibrotic myeloproliferative neoplasms (MPN). MPN-BMSC showed decreased capacity to stimulate the proliferation of colony-forming units of normal hematopoietic stem and progenitor cells and displayed increased matrix remodelling (in particular fibronectin deposition) compared to control BMSC. This finding was confirmed in pre-fibrotic MPN bone marrow biopsies in a tissue microarray (n = 34), which stained positive for fibronectin in the absence of reticulin as a standard myelofibrosis marker. Fibronectin expression correlated significantly with reduced haemoglobin levels in MPN-patients (p = 0.007; R2 = 0.42). Our data show significant cell-intrinsic alterations in MPN-MSC and suggest that Fibronectin expression might be applicable as a biomarker for the identification of early myelofibrotic transformation in reticulin-negative MPN.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271470 | PMC |
| http://dx.doi.org/10.1186/s13045-014-0092-2 | DOI Listing |
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