Comorbid bipolar disorder and borderline personality disorder and substance use disorder.

J Nerv Ment Dis

*Department of Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Catalonia, Spain; and †Department of Psychiatry and Human Behavior, Brown Medical School, and the Department of Psychiatry, Rhode Island Hospital, Providence, Rhode Island.

Published: January 2015

AI Article Synopsis

  • Bipolar disorder (BD) and borderline personality disorder (BPD) are serious mental health conditions that often occur together and increase the risk of substance use disorders (SUD).
  • In a study of 3,651 psychiatric patients, those diagnosed with both BD (Type I or II) and BPD had a significantly higher rate of SUD (76%) compared to those with only BDII (50%).
  • The findings highlight the need to consider both disorders together in treatment, as their co-occurrence significantly heightens the risk of developing a substance use problem.

Article Abstract

Bipolar disorder (BD) and borderline personality disorder (BPD) are disabling and life-threatening conditions. Both disorders share relevant comorbidities, particularly the risk of having a lifetime substance use disorder (SUD). We tested the hypothesis that patients with both BD type I (BDI) or II (BDII) and BPD would have a higher rate of SUD than would patients with either disorder alone. A total of 3651 psychiatric patients were evaluated with semistructured diagnostic interviews for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, axis I and II disorders. A total of 63 patients were diagnosed with both BD and BPD, and these patients were significantly more likely to have a SUD compared with BDII patients without BPD (76% vs. 50%, χ = 9.69, p < 0.01). There were no differences when comparing the comorbid group with BPD patients without BD (76% vs. 71%, χ = 0.519, p = 0.4). The present study shows the importance of taking both BPD and BD into consideration insofar as the co-occurrence of the disorders increased the risk of having a SUD especially when compared with BDII alone.

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http://dx.doi.org/10.1097/NMD.0000000000000235DOI Listing

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