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A novel MXI1-NUTM2B fusion detected in an undifferentiated ovarian cancer.
Gynecol Oncol Rep
February 2025
Division of Gynecologic Oncology, Karmanos Cancer Institute, Wayne State University, 4100 John R St, Detroit, MI 48202, USA.
Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trial.
EClinicalMedicine
January 2025
Canadian Cancer Trials Group, Queen's University, Kingston, ON, Canada.
Background: Dual inhibition of cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmed death ligand 1 (PD-L1) has been shown to be an effective treatment strategy in many cancers. We sought to determine the objective response rate of combination durvalumab (D) plus tremelimumab (TM) in parallel cohorts of patients with carefully selected rare cancer types in which these agents had not previously been evaluated in phase II trials and for which there was clinical or biological rationale for dual immune checkpoint inhibitor therapy to be active.
Methods: We designed a multi-centre, non-blinded, open-label phase II basket trial with each of the following 8 rare cancers considered a separate phase II trial: salivary carcinoma, carcinoma of unknown primary (CUP) with tumour infiltrating lymphocytes and/or expressing PD-L1, mucosal melanoma, acral melanoma, osteosarcoma, undifferentiated pleomorphic sarcoma, clear cell carcinoma of the ovary (CCCO) or squamous cell carcinoma of the anal canal (SCCA).
Histological and immunohistochemical analysis of gonadal development in the veiled chameleon (Chamaeleo calyptratus).
Anat Rec (Hoboken)
December 2024
Department of Comparative Anatomy, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland.
Chameleons are a family of lizards distinguished by several unique features related to their arboreal lifestyles, such as a ballistic tongue, skin color changes, independent movement of both eyes, a prehensile tail, and cleft hands and feet. The veiled chameleon (Chamaeleo calyptratus) has been proposed as a promising model species for studying squamate biology. Despite its potential, the developmental biology of this species remains poorly understood, particularly in terms of gonadal development.
View Article and Find Full Text PDFArticle Synopsis
- - Bisphenol-A (BPA), a common chemical in plastics, negatively impacts fertility, but its specific effects on early ovarian development in mammals, particularly marsupials like the tammar wallaby, are not well understood.
- - The study observed key ovarian development markers at specific intervals from birth to 10 days post-partum, revealing that ovarian differentiation begins around days 2-4, with significant changes in gene expression and protein localization.
- - BPA exposure during the critical early days of development suppressed normal ovarian differentiation, inhibiting the formation of ovarian structures and reducing the expression of important differentiation genes at day 10 post-partum.
Resveratrol inhibits Lin28A expression and induces its degradation via the proteasomal pathway in NCCIT cells.
Oncol Lett
December 2024
Biomedical Cancer Research Unit, Biomedical Research Institute, National Autonomous University of Mexico/National Cancer Institute, Mexico City 14080, Mexico.
Lin28A is an oncoprotein overexpressed in several cancer types such as testicular, ovarian, colon, breast and lung cancers. As a pluripotency factor that promotes tumorigenesis, Lin28A is associated with more undifferentiated and aggressive tumors phenotypes. Moreover, Lin28A is a highly stable protein that is difficult to downregulate.
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