Pulmonary actinomycosis is a rare disease that is often misdiagnosed as tuberculosis or lung cancer. Actinomyces graevenitzii is a relatively new recognized Actinomyces species isolated from various clinical samples. The authors report a case of pulmonary actinomycosis caused by A graevenitzii. A computed tomography examination revealed an excavated consolidation in the middle right lobe of a previously healthy young man who presented with a long history of moderate cough. Cultures of the bronchoalveolar lavage fluid confirmed the diagnosis of pulmonary abscess caused by A gravenitzii. At the three-month follow-up consultation and, after six weeks of high-dose amoxicillin, the pulmonary lesion had completely disappeared.
Department of Agricultural, Forestry, Food and Environmental Sciences (DAFE), University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
- The study investigates the oral microbiota differences between healthy individuals and those with sickle cell anemia (SCA) in the Middle East, highlighting the need for more research on this genetic disorder.
- Saliva samples from 36 participants (18 with SCA and 18 healthy controls) were analyzed using next-generation sequencing to identify and quantify various bacterial species in their oral microbiomes.
- Findings reveal that alterations in the oral microbiota may increase health complications for SCA patients, suggesting that salivary diagnostics could be useful for predicting and preventing related diseases in the future.
* A 51-year-old male with a history of cancer initially presented with severe pain and headaches, mistakenly thought to be a cancer recurrence, but was ultimately diagnosed with actinomycosis after thorough examinations.
* Treatment involved long-term antibiotic therapy, highlighting the importance of recognizing actinomycosis in patients with complex medical histories to ensure timely and appropriate care.
Background: Microbiota may be associated with esophageal squamous cell carcinoma (ESCC) development. However, it is not known the predictive value of microbial biomarkers combining epidemiological factors for the early detection of ESCC and precancerous lesions.
Methods: A total of 449 specimens (esophageal swabs and saliva) were collected from 349 participants with different esophageal statuses in China to explore and validate ESCC-associated microbial biomarkers from genes level to species level by 16S rRNA sequencing, metagenomic sequencing and real-time quantitative polymerase chain reaction.
organisms reside on mucosal surfaces of the oropharynx and the genitourinary tract. Polymicrobial infections with organisms are increasingly being reported in the literature. Since these infections differ from classical actinomycosis, lacking of specific clinical and imaging findings, slow-growing organisms can be regarded as contaminants or insignificant findings.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background: The human lung serves as a niche for a unique and dynamic bacterial community related to the development and aggravation of multiple respiratory diseases. Therefore, identifying the microbiome status is crucial to maintaining the microecological balance and maximizing the therapeutic effect on lung diseases. Therefore, we investigated the histological type-based differences in the lung microbiomes of patients with lung cancer.
