In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262193 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110393 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Effects of mild cognitive impairment and sleep disorders on the minimum alveolar concentration value of sevoflurane.
BMC Anesthesiol
December 2024
Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, Hebei, China.
Objectives: To explore the effect of mild cognitive impairment (MCI) and MCI with sleep disorders on the potency of sevoflurane anesthesia in the elderly.
Design: Prospective study methods. Dixon up-and-down methods.
Spatio-temporal evolution and obstacle diagnosis of human settlements based on the "production-living-ecological" functions.
Sci Rep
December 2024
School of Geography, Liaoning Normal University, Dalian, 116029, China.
Sustainable development is a hot topic of global concern and sustainable human settlements (HS) are crucial to people's happiness. Thus, strengthening the construction of HS will help enrich human settlements geography with theories of HS interactions, clarify the existing problems of the Chengdu-Chongqing urban agglomeration (CC), promote the harmonization of the human-land relationship, and realize the SDGs. The results were as follows.
View Article and Find Full Text PDFDeath and hospital contact in a cohort from Thyborøn-Harboøre an environmentally contaminated site in Denmark.
Sci Rep
December 2024
Omicron, Telefonvej 8D, 2nd, Søborg, 2860, Denmark.
We studied mortality and hospital contact in people from Thyborøn-Harboøre, an environmentally contaminated fishing community on the Danish West Coast. The population and a comparison group from other fishing communities on the Danish West Coast were identified from historical data in the Central Population Register. All persons were followed up for death and hospital contacts to March 2023.
View Article and Find Full Text PDFRecommendations to reduce and prevent negative health outcomes and healthcare costs among night shift nurses: An AAN consensus paper.
Nurs Outlook
December 2024
School of Nursing, University of Pittsburgh, Pittsburgh, PA.
A growing body of evidence demonstrates occupational night shift hazards. Decades of research point to health risks for nurses contributing to chronic diseases, including diabetes, cardiovascular disease, cognitive/mental health, and cancers-all associated with earlier mortality. Patient safety, recruitment and retention of quality nursing workforce, and related costs are important concerns associated with night shift work.
View Article and Find Full Text PDFPublic exposure from inhalation of radon and thoron around the tin mine and smelter areas in Bangka, Indonesia.
Sci Rep
December 2024
Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, 036-8564, Aomori, Japan.
Radon (Rn) and thoron (Rn) were reported as the highest contributors to natural radiation received by humans. Furthermore, radon has been stated as the second-highest cause of lung cancer. The concentrations of U and Th (the parent nuclide of radon and thoron, respectively) in nature vary with geological conditions and can be enhanced by human activities.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!