AI Article Synopsis
- The study aimed to predict fetal growth restriction (FGR) by examining mRNA levels of the Flt-1 gene in the blood of pregnant women.
- Researchers compared plasma samples from 11 women with FGR to 88 healthy controls across all three trimesters.
- Results showed that Flt-1 levels were significantly higher in the FGR group, and the method demonstrated a 60% detection rate at a low false-positive rate, suggesting it could be an effective early warning marker for FGR.
Article Abstract
Objective: To predict the occurrence of fetal growth restriction (FGR) by analyzing messenger RNA (mRNA) expression levels of vascular endothelial growth factor receptor 1 (fms-like tyrosine kinase 1 [Flt-1]) in maternal blood.
Study Design: Eleven women with FGR were matched with 88 controls. Plasma samples were obtained during each trimester. The Flt-1 mRNA expression levels were compared between groups. Predicted probabilities were calculated, and sensitivity-specificity (receiver-operating characteristic [ROC]) curves were assessed based on regression models for each trimester measurement and possible combinations of measurements.
Results: The mRNA levels of the FGR group during all trimesters were significantly higher than those of the control group. The ROC curve of combined first and second trimester data yielded a detection rate of 60% at a 10% false-positive rate, with an area under curve of 0.79.
Conclusion: The Flt-1 mRNA expression in maternal blood can be used as a marker to predict the development of FGR, long before a clinical diagnosis is made.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502802 | PMC |
| http://dx.doi.org/10.1177/1933719114557895 | DOI Listing |
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