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| http://dx.doi.org/10.1371/journal.pbio.1002014 | DOI Listing |
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Comparative analysis the chloroplast genomes of Celastrus (Celastraceae) species: Provide insights into molecular evolution, species identification and phylogenetic relationships.
Phytomedicine
August 2024
School of Life Sciences and Biopharmaceutics, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, 510006, China. Electronic address:
Background: The genus Celastrus is an important medicinal plant resource. The similarity of morphology and the lack of complete chloroplast genome analysis have significantly impeded the exploration of species identification, molecular evolution and phylogeny of Celastrus.
Purpose: In order to resolve the phylogenic controversy of Celastrus species, the chloroplast genome comparative analysis was performed to provide genetic evidence.
Different Patterns of Codon Usage and Amino Acid Composition across Primate Lentiviruses.
Viruses
July 2023
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
A common feature of the mammalian (family ) is an RNA genome that contains an extremely high frequency of adenine (31.7-38.2%) while being extremely poor in cytosine (13.
View Article and Find Full Text PDFInsight on genetic features prevalent in five Ipomoea species using comparative codon pattern analysis reveals differences in major codons and reduced GC content at the 5' end of CDS.
Biochem Biophys Res Commun
May 2023
School of Life Sciences, Jiangsu Normal University, Xuzhou, China. Electronic address:
Article Synopsis
- Ipomoea plants are significant for commercial, medicinal, and ornamental purposes, but their evolutionary relationships remain poorly understood.
- This study analyzed the codon usage bias (CUB) among five species of Ipomoea to uncover these relationships, using various plots and calculations related to codon usage.
- Findings indicated minimal differences in CUB across the species, with notable variations in the optimal codons at the 5'-end of the coding sequence, which could help explain the evolutionary dynamics within the genus.
Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria.
bioRxiv
March 2023
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, USA.
Unlabelled: Each genome encodes some codons more frequently than their synonyms (codon usage bias), but codons are also arranged more frequently into specific pairs (codon pair bias). Recoding viral genomes and yeast or bacterial genes with non-optimal codon pairs has been shown to decrease gene expression. Gene expression is thus importantly regulated not only by the use of particular codons but by their proper juxtaposition.
View Article and Find Full Text PDFKRAS codon 12 mutations characterize a subset of de novo proliferating "metaplastic" Warthin tumors.
Virchows Arch
May 2023
Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Krankenhausstraße 8-10, 91054, Erlangen, Germany.
Warthin tumor (WT; synonym: cystadenolymphoma) represents one of the most frequent salivary gland tumors with a frequency equaling or even outnumbering that of pleomorphic adenomas in some series. Histologically, the tumor displays tall columnar oncocytic cells, arranged into two cell-thick layers lining variably cystic glands within an organoid lymphoid stroma. Tumors with exuberant squamous metaplasia in response to FNA-induced or other types of tissue injury/infarction have been referred to as "metaplastic WTs.
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