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Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial Infarction by Activating β-Arrestin-2, Protein Phosphatase 2A, and Glycogen Synthase Kinase-3 and Inhibiting β-Catenin.
Cardiovasc Drugs Ther
December 2021
Department of Clinical Cardiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Purpose: This study tested if the protective anti-remodeling effect of GLP-1 agonist Exendin-4 after an acute myocardial infarction (MI) in rats involves inhibition of the Wnt1/β-catenin signaling pathway.
Methods: Rats were divided into sham, sham + Exendin-4 (10 μg/day, i.p), MI, and MI + Exendin-4.
Role of Wnt signaling pathway in progression of sinonasal inverted papilloma to squamous cell carcinoma.
Am J Rhinol Allergy
February 2016
Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon-Si, Republic of Korea.
Background: Sinonasal inverted papilloma (IP) is one of the most common benign tumors of the sinonasal area and malignant transformation has frequently been reported. However, the exact mechanism of the transition from benign lesion to malignancy is not known. The Wnt signaling pathway involves a network of multiple signaling glycoproteins that are known to play an important role in embryogenesis and carcinogenesis.
View Article and Find Full Text PDFWnt-1 dishevelled signaling functionally links calcium-calmodulin-dependent protein kinase II and cardiac dysfunction.
Hypertension
February 2015
From the Department of Physiology and Pathophysiology, Faculty of Health Sciences, College of Medicine, The Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Wnt signaling pathway in non-small cell lung cancer.
J Natl Cancer Inst
January 2014
Affiliation of author: Division of Medical Oncology, University of Ottawa, Ottawa, ON, Canada.
Wnt/β-catenin alterations are prominent in human malignancies. In non-small cell lung cancer (NSCLC), β-catenin and APC mutations are uncommon, but Wnt signaling is important in NSCLC cell lines, and Wnt inhibition reduces proliferation. Overexpression of Wnt-1, -2, -3, and -5a and of Wnt-pathway components Frizzled-8, Dishevelled, Porcupine, and TCF-4 is common in resected NSCLC and is associated with poor prognosis.
View Article and Find Full Text PDFIdentification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein.
J Biol Chem
December 2010
Department of Structural Biology, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA.
Wnt signaling pathways are involved in embryonic development and adult tissue maintenance and have been implicated in tumorigenesis. Dishevelled (Dvl/Dsh) protein is one of key components in Wnt signaling and plays essential roles in regulating these pathways through protein-protein interactions. Identifying and characterizing Dvl-binding proteins are key steps toward understanding biological functions.
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