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Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case-control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD.

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Objective: To compare the mineral levels in umbilical vein and artery serum and to analyze the relationship between newborn birth weight and the mineral levels in umbilical vein and artery serum by measuring the mineral levels in umbilical vein and artery serum.

Methods: A cross-sectional study was conducted to recruit 101 pairs of maternal and newborn who were hospitalized in Danyang People's Hospital, Jiangsu Province from June to September 2021 as the participants. After delivery, umbilical vein and artery blood were collected, and the levels of manganese(Mn), iron(Fe), cobalt(Co), copper(Cu), zinc(Zn), selenium(Se), magnesium(Mg) and calcium(Ca) in umbilical vein and artery serum were detected by inductively coupled plasma mass spectrum(ICP-MS).

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Prenatal metals and offspring cognitive development: Insights from a large-scale placental bioassay study.

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December 2024

School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (AHMU), MOE, Hefei 230032, China; NHC Key Laboratory of study on abnormal gametes and reproductive tract, Hefei 230032, China; Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Hefei, 230032, China. Electronic address:

Article Synopsis
  • The developing fetus is highly sensitive to neurotoxic metals, and this study uses placenta as a key biomarker for monitoring such exposures during pregnancy.
  • Conducted as part of the Ma'anshan Birth Cohort (MABC) in China, the research analyzed the effects of both non-essential and essential metals (like arsenic, cadmium, mercury, and zinc) on cognitive development in children, involving 1,586 mother-child pairs.
  • Results showed negative associations between elevated levels of certain metals, especially arsenic and cadmium, with cognitive tasks measured by the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV), with findings also indicating varied effects based on the sex of the children.
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Demands for animal products are projected to increase in the future, and animal production is key to agricultural sustainability and food security; consequently, enhancing ruminant livestock production efficiencies in sustainable ways is a major goal for the livestock industry. Developmental programming is the concept that various stressors, including compromised maternal nutrition during critical developmental windows will result in both short- and long-term changes in the offspring. Ruminant models of developmental programming indicate that compromised maternal nutrition, including global under and over-nutrition, macronutrients, and specific micronutrients, including amino acids (Met and Arg), vitamins (folate, B, and choline), and minerals (sulfur, cobalt, and selenium) can alter offspring outcomes.

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Background: The composition of maternal gut phylum in each trimester of pregnancy has been associated with fetal development, separately. Diet is a main effective factor on the gut composition of phylum. However, associations between dietary glycemic index (GI), load (GL) and total antioxidant capacity (TAC) not studied with the gut population of phylum in mothers at the first trimester of pregnancy.

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