AI Article Synopsis
- * A new mouse monoclonal antibody, SpAKKAA-mAb 3F6, has been developed to target and neutralize a specific protein from S. aureus that aids in immune evasion, showing promise in protecting neonatal mice from sepsis and helping them build immunity.
- * Researchers have created a humanized version of this antibody, which has also demonstrated protective effects in neonatal mice and is set to be tested in clinical trials for VLBW infants.
Article Abstract
Staphylococcus aureus is a cause of sepsis and meningitis in very-low-birth-weight (VLBW) infants. Clinical trials with S. aureus specific antibodies failed to protect VLBW neonates, which may be due to the immune evasive attributes of staphylococcal protein A (SpA). Here we show that mouse monoclonal antibody SpAKKAA-mAb 3F6, which neutralizes the immunoglobulin Fcγ-binding and B cell receptor crosslinking attributes of SpA, protects neonatal mice against S. aureus sepsis and raises protective immunity against subsequent staphylococcal infection. We developed a humanized SpAKKAA-mAb that protects neonatal mice against S. aureus sepsis and may therefore be subjected to clinical testing in VLBW neonates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378561 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2014.11.051 | DOI Listing |
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