Objective: Perineural invasion (PNI) is frequent in oral squamous cell carcinoma (OSCC) and could play an important role in treatment decisions.
Study Design: This retrospective study used multivariate analysis to evaluate the impact of PNI on locoregional recurrence, neck metastases, and survival in 236 consecutive patients with oral cancer.
Results: There were significant differences in the local (P = .007) and regional (P = .041) failure rates in the PNI-positive group compared with the PNI-negative group. Univariate analysis demonstrated that PNI-positive patients had significantly worse locoregional control (P = .011), disease-specific survival (P = .023), and overall survival (P = .046) compared with PNI-negative patients.
Conclusion: PNI was an independent predictor of local and regional failure in a well-defined, homogeneous population with OSCC.
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| http://dx.doi.org/10.1016/j.oooo.2014.10.004 | DOI Listing |
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