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Sleep-Disordered Breathing in Patients with Chronic Heart Failure and Its Implications on Real-Time Hemodynamic Regulation, Baroreceptor Reflex Sensitivity, and Survival.
J Clin Med
November 2024
Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, Clinic Floridsdorf, 1210 Vienna, Austria.
Impairment in autonomic activity is a prognostic marker in patients with heart failure (HF), and its involvement has been suggested in cardiovascular complications of obstructive sleep apnea syndrome (OSAS) and Cheyne-Stokes respiration (CSR). This prospective observational study aims to investigate the implications of sleep-disordered breathing (SDB) on hemodynamic regulation and autonomic activity in chronic HF patients. Chronic HF patients, providing confirmation of reduced ejection fraction (≤35%), underwent polysomnography, real-time hemodynamic, heart rate variability (HRV), and baroreceptor reflex sensitivity (BRS) assessments using the Task Force Monitor.
View Article and Find Full Text PDF[Real-world efficacy and safety of baroreceptor activation therapy in a series of patients with refractory arterial hypertension].
Hipertens Riesgo Vasc
December 2024
Unidad de Riesgo Vascular, Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, España.
The number of patients suffering from refractory hypertension and advanced-stage chronic heart failure (CHF) is progressively increasing. In recent years, device-mediated therapies have been developed as an alternative or adjunct to conventional medical treatment. Our primary objective is to describe the clinical experience in a series of patients with refractory hypertension following the implantation of baroreceptor activation therapy (BAT).
View Article and Find Full Text PDFBaroreflex activation therapy through electrical carotid sinus stimulation.
Auton Neurosci
December 2024
Department for Cardiology, Angiology, Pneumology and Intensive Care Medicine, University of Cologne, Germany; Department of Cardiology and Intensive Care Medicine, Ev. Krankenhaus Köln-Weyertal, Cologne, Germany.
An imbalance between cardiovascular parasympathetic and sympathetic activity towards sympathetic predominance has been implicated in the pathogenesis of treatment-resistant arterial hypertension and heart failure. Arterial baroreceptors control efferent cardiovascular autonomic activity and have, therefore, been recognized as potential treatment targets. Baroreflex activation therapy through electrical carotid sinus stimulation is a device-based approach to modulate cardiovascular autonomic activity.
View Article and Find Full Text PDFUnveiling novel molecules and therapeutic targets in hypertension - A narrative review.
Eur J Pharmacol
December 2024
MP Shah Medical College, Gujarat, India.
Article Synopsis
- * Current treatments mainly focus on the renin-angiotensin-aldosterone system but often provide limited success, leading some patients to develop treatment-resistant hypertension.
- * New therapies are emerging that target different aspects of hypertension, including the nervous system and inflammation, but they face significant challenges that could affect their effectiveness and acceptability in long-term use.
Baroreflex activation therapy in advanced heart failure: A long-term follow-up.
ESC Heart Fail
October 2024
Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany.
Aims: Baroreceptor activation therapy (BAT) is a promising new treatment strategy for patients with heart failure with reduced ejection fraction (HFrEF). It provides symptomatic relief, improvement in left ventricular function and reduction of cardiac biomarkers. Data regarding the long-term effect of BAT on HFrEF are scarce.
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