AI Article Synopsis
- * Recent studies show that analyzing miRNA expression can help differentiate between various types of cancer, highlighting their importance in cancer research.
- * This paper focuses on using miRNA profiles in breast cancer samples to identify distinct cancer subtypes, showing that miRNAs have unique signatures that can reveal new subtypes and link to survival outcomes.
Article Abstract
MicroRNAs (miRNAs) are a kind of short non-coding RNAs, of about 22 nucleotides in length, which modulate and sometimes degrade the target mRNAs thereby regulating a number of cellular functions. Recent research in this area establishes the involvement of miRNAs in various disease progressions, including certain types of cancer development. Further, genome-wide expression profiling of miRNAs has been proven to be useful for differentiating various cancer types. In this paper, we have used miRNA expression profiles over a large set of breast cancer tumor samples for identifying subtypes of breast cancers. The experimental results demonstrate that miRNAs carry a unique signature that distinguishes cancer subtypes and reveal new cancer subtypes. Additional survival analyses based on clinical data also strengthen this claim.
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| http://dx.doi.org/10.1016/j.gene.2014.11.053 | DOI Listing |
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