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| http://dx.doi.org/10.4161/15384101.2014.966580 | DOI Listing |
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p27/Kip1 functions as a tumor suppressor and oncoprotein in osteosarcoma.
Sci Rep
April 2019
Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, 19803, USA.
The p27/kip1 (p27) tumor suppressor inhibits cyclin/cyclin-dependent kinase (CDK) complexes and halts cell cycle progression. p27 further regulates invasion and migration in cancer cells, suggesting p27 also functions as an oncoprotein. Using a human osteosarcoma tissue microarray we identified high expression of cytoplasmic p27 in metastatic tumors.
View Article and Find Full Text PDFp27(Kip1) and STMN1: partners again?
Cell Cycle
May 2015
a Vermont Cancer Center ; University of Vermont, Burlington , NY USA.
Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas.
Gynecol Oncol
October 2011
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
Background: Most high-grade pelvic serous carcinomas (HGPSCs) arise from fallopian tube epithelium (FTE). To date, few markers have been shown to characterize FTE transformation. Stathmin 1 (STMN1) is a candidate oncogene whose activity is influenced by p53, p27Kip1 (p27), and PI3K/Akt pathway activation.
View Article and Find Full Text PDFp27(Kip1) and stathmin share the stage for the first time.
Trends Cell Biol
July 2005
Division of Hematology/Oncology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.
Cell migration is essential for development, morphogenesis, tissue repair and tumor metastasis. p27(Kip1) and stathmin are two cell-cycle-regulatory proteins that were recently shown to play important roles in the regulation of cell migration. In this article, we discuss a new study that places p27(Kip1) and stathmin in the same pathway by showing that stathmin, a microtubule-regulatory protein, mediates the effects of p27(Kip1) on cell motility.
View Article and Find Full Text PDFp27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion.
Cancer Cell
January 2005
Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano 33081, Italy.
Emerging evidences suggest that cyclin-dependent kinase inhibitors (CKIs) can regulate cellular functions other than cell cycle progression, such as differentiation and migration. Here, we report that cytoplasmic expression of p27(kip1) affects microtubule (MT) stability following cell adhesion on extracellular matrix (ECM) constituents. This p27(kip1) activity is due to its ability to bind and impair the function of the MT-destabilizing protein stathmin.
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