AI Article Synopsis
- Protein-carbohydrate interactions are crucial for regulating how cells interact with each other and their environment, influencing important biological processes like growth, immune response, and cancer spread.
- Galectin-3 is a multifunctional protein that plays a role in normal growth and cancer progression, but how it works at a molecular level is not fully understood.
- This review covers the structure and binding characteristics of Galectin-3, how it's regulated at the gene level, and its involvement in cell adhesion, blood vessel formation, and programmed cell death.
Article Abstract
Protein-carbohydrate interactions play significant role in modulating cell-cell and cell-extracellular matrix interactions, which, in turn, mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding protein family, is found multifunctional and is involved in normal growth development as well as cancer progression and metastasis, but the detailed mechanisms of its functions are not well understood. This review discusses its structure, binding properties, transcriptional regulation and roles in homotypic/heterotypic cell adhesion, angiogenesis and apoptosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254724 | PMC |
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