AI Article Synopsis
- The incidence of nonmelanoma skin cancer (NMSC) is rising due to factors like aging and sun exposure, leading to a need for alternative treatment approaches.
- Research is focusing on identifying compounds that could help prevent or reverse the biochemical changes associated with skin cancer through non-surgical methods.
- Combining various pharmacological agents with current treatments, like topical sunscreens, shows promise for developing innovative and effective therapies for NMSC.
Article Abstract
The incidence of nonmelanoma skin cancer (NMSC) continues to rise, partly because of aging, the frequency of early childhood sunburns, and sporadic extreme recreational sun exposure. A nonsurgical approach to selected cutaneous malignancy could possibly reduce the cost as well as morbidity of surgical treatment for NMSC. There has been growing interest in isolating compounds that could suppress or reverse the biochemical changes necessary for cutaneous malignancies to progress by pharmacologic intervention. By targeting diverse pathways recognized as important in the pathogenesis of nonmelanoma skin cancers, a combination approach with multiple agents or addition of chemopreventative agents to topical sunscreens may offer the potential for novel and synergistic therapies in treating nonmelanoma skin cancer. This preliminary information will expand to include more therapeutic options for NMSC in the future.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248487 | PMC |
| http://dx.doi.org/10.4103/0019-5154.143503 | DOI Listing |
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