In the last decade, several mouse models for RhoA, Rac1, and Cdc42 have emerged and have contributed a great deal to understanding the precise functions of Rho GTPases at early stages of development. This review summarizes our current knowledge of various mouse models of tissue-specific ablation of Cdc42, Rac1, and RhoA with emphasis on early embryogenesis, epithelial and skin morphogenesis, tubulogenesis, development of the central nervous system, and limb development.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601498 | PMC |
| http://dx.doi.org/10.4161/sgtp.29716 | DOI Listing |
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