Eph:ephrin signaling plays an important role in embryonic development as well as tissue homeostasis in the adult. At the cellular level, this transduction pathway is best known for its role in the control of cell adhesion and repulsion, cell migration and morphogenesis. Yet, a number of publications have also implicated Eph:ephrin signaling in the control of adult and embryonic neurogenesis. As is the case for other biological processes, these studies have reported conflicting and sometimes opposite roles for Eph:ephrin signaling in neurogenesis. Herein, we review these studies and we discuss existing mathematical models of stem cell dynamics and neurogenesis that provide a coherent framework and may help reconcile conflicting results.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594309 | PMC |
| http://dx.doi.org/10.4161/19336918.2014.969990 | DOI Listing |
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Article Synopsis
- EphrinB2 is crucial for promoting the formation of blood and lymph vessels during embryo development and plays a significant role in cardiac lymphangiogenesis after a heart attack (myocardial infarction, MI).
- The study found that EphrinB2 helps prevent heart remodeling and dysfunction post-MI by activating pathways involved in lymphangiogenesis, with its absence leading to worsening heart conditions.
- Mechanistically, EphrinB2 enhances the proliferation and migration of lymphatic endothelial cells, boosts the activity of a specific transcription factor (ISL1), and its effects are diminished when the VEGFR3 pathway is inhibited, highlighting its importance in cardiac recovery after MI.
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