A systems biology approach to iron metabolism.

Adv Exp Med Biol

Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Published: April 2015

Iron is critical to the survival of almost all living organisms. However, inappropriately low or high levels of iron are detrimental and contribute to a wide range of diseases. Recent advances in the study of iron metabolism have revealed multiple intricate pathways that are essential to the maintenance of iron homeostasis. Further, iron regulation involves processes at several scales, ranging from the subcellular to the organismal. This complexity makes a systems biology approach crucial, with its enabling technology of computational models based on a mathematical description of regulatory systems. Systems biology may represent a new strategy for understanding imbalances in iron metabolism and their underlying causes.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464783PMC
http://dx.doi.org/10.1007/978-1-4939-2095-2_10DOI Listing

Publication Analysis

Top Keywords

systems biology
12
iron metabolism
12
biology approach
8
iron
7
systems
4
approach iron
4
metabolism iron
4
iron critical
4
critical survival
4
survival living
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!