Bacterial biofilms are estimated to be associated with over 65 percent of all nosocomial infections. However, no therapeutics have been approved by the FDA which directly mediate biofilm formation or persistence. Herein we report oxazine as a highly potent inhibitor, disperser and in the presence of the appropriate antibiotic eradicator of V. cholerae biofilms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288701 | PMC |
| http://dx.doi.org/10.1039/c4cc07003h | DOI Listing |
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Regioselective Brønsted acid catalyzed ring opening of aziridines by phenols and thiophenols; a gateway to access functionalized indolines, indoles, benzothiazines, dihydrobenzo-thiazines, benzo-oxazines and benzochromenes.
Org Biomol Chem
July 2024
Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata - 700 009, West Bengal, India.
Brønsted acid catalyzed regioselective ring opening of aziridines by phenols and thiophenols have been reported. Involvement of a series of aziridines with a range of phenols and thiophenols offer the generality of the reported protocol. Completion of the reaction at room temperature within very short time brings the uniqueness of the developed technique.
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