Selective meta-arylation of O-β-naphthyl carbamate has been accomplished using Pd(OAc)2 as a catalyst precursor and K2S2O8 with AgOAc as the oxidant. A range of aryl boronic acids could be introduced in moderate to good yields. Mechanistic investigation shows that the carbamate substituent has a unique effect and the reaction undergoes an ortho-carbometallation/meta-direct arylation process.
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http://dx.doi.org/10.1039/c4cc07997c | DOI Listing |
Neurochem Res
January 2025
Department of Physiology, Faculty of Medicine, University of Ondokuz Mayıs, Samsun, Türkiye.
In the present study, the effects of the acetylcholinesterase (AChE) enzyme inhibitor rivastigmine (RIVA) on spike-wave discharges (SWDs), memory impairment, anxiety-like behavior, and the transient receptor potential vanilloid 1 (TRPV1) gene expression were investigated in genetic absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. After tripolar electrodes were implanted on the WAG/Rij rats' skulls, single doses of 0.125, 0.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Amity Institute of Pharmacy, Amity University, Gurugram, Haryana, India.
Background: The current study aimed to investigate the chemical interaction of naringenin with the possible receptors and enzymes involved in the pathogenesis of cognitive deficits and tested their ADME and toxicity. Furthermore, in-vivo studies have also done to evaluate the effect of naringenin and its nanoparticles on STZ-induced cognitive decline in mice.
Method: Naringenin were evaluated against the active sites of β-secretase 1 (PDB: 3UQU), human insulin-degrading enzyme (PDB: 4RE9), insulin receptor tyrosine kinase (PDB: 1IR3), glycogen synthase kinase-3 β (PDB: 3L1S), phosphoprotein phosphatase 2A (PDB: 3P71), human superoxide dismutase I (PDB: 5YT0), catalase-3 (PDB:3EJ6), and human acetylcholinesterase (PDB: 4EY7) in comparison of rivastigmine using molecular docking studies.
Front Physiol
December 2024
Institute of Disinfection and Pest Control, Beijing Center for Disease Prevention and Control, Beijing, China.
Background: (Skuse) is an invasive and widespread mosquito species that can transmit dengue, chikungunya, yellow fever, and Zika viruses. Its control heavily relies on the use of insecticides. However, the efficacy of the insecticide-based intervention is threatened by the increasing development of resistance to available insecticides.
View Article and Find Full Text PDFACS Catal
December 2024
Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
A Rh(III)-catalyzed sequential C-H bond addition to dienes and in situ formed aldimines was developed, allowing for the preparation of otherwise challenging to access amines with quaternary centers at the -position. A broad range of dienes were effective inputs and installed a variety of aryl and alkyl substituents at the quaternary carbon site. Aryl and alkyl sulfonamide and carbamate nitrogen substituents were incorporated by using different formaldimine precursors.
View Article and Find Full Text PDFACS Omega
December 2024
Departamento de Química, Instituto Tecnológico de Aeronáutica, São José dos Campos, São Paulo CEP 12228-900, Brazil.
The five-coordinate complex [RuCl(PNP)] () was synthesized from the binuclear [RuCl(-cym)] with a PNP-type ligand (PNP = 3,6-di--butyl-1,8-bis(dipropylphosphino)methyl)-9-carbazole - (Cbzdiphos )H) in a toluene solution, within 20 h at 110 °C, producing a green solid, which was precipitated with a 1/1 mixture of - pentane/HMDSO. The complex was characterized by NMR-H, C, and P{H}, mass spectroscopy-LIFDI, FTIR, UV/vis spectroscopy, and cyclic voltammetry, as well as a description of the optimized structure by DFT calculation. The reactivity of was investigated in the presence of potassium triethylborohydride (KBEtH, in THF solution of 1.
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