Background: Candida and epithelial dysplasia have long been associated with oro-mucosal lesions.
Aim And Objective: The present study was designed to evaluate the correlation between presence of Candida organisms and epithelial dysplasia in various oral mucosal lesions associated with areca nut and tobacco use.
Materials And Methods: A total of 50 individuals were selected, between age range of 19-70 y. Three separate cytosmears were prepared for each participant. All the slides were stained with PAS stain and the best slide was viewed for candidal organisms.
Statistical Tests: The data was analysed using the SPSS version16. Chi square test was performed.
Results: Out of these, samples of 26 participants displayed presence of Candida. It was further observed that all the samples that were positive for presence of Candida displayed the organism in hyphal form. Out of 50 biopsy specimens stained for presence of Candida using PAS stain, samples of only 2 participants demonstrated presence of Candida in hyphal form, whereas the biopsy specimens stained for demonstrating dysplastic changes using H&E stain displayed various levels of cellular atypia in samples of 16 participants. Out of these 12 were mild, 3 were moderate & 1 displayed severe dysplastic changes.
Conclusion: The study revealed a statistically non significant correlation between the presence of Candida and epithelial dysplasia in oral mucosal lesions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253261 | PMC |
| http://dx.doi.org/10.7860/JCDR/2014/9872.4956 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Role of amino acid substitutions on proteolytic stability of histatin 5 in the presence of secreted aspartyl proteases and salivary proteases.
Protein Sci
January 2025
Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland, USA.
Histatin 5 (Hst5) is a 24-amino-acid peptide naturally present in human saliva that has been proposed as a potential antifungal therapeutic. However, Hst5 is susceptible to degradation by secreted aspartyl proteases (Saps) produced by Candida albicans, which could limit its efficacy as a therapeutic. To better understand the role of the lysine residues of Hst5 in proteolysis by C.
View Article and Find Full Text PDFmutation in decreases manogepix susceptibility owing to increased expression.
Antimicrob Agents Chemother
December 2024
Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
is an emerging pathogenic fungus that is highly resistant to existing antifungal drugs. Manogepix is a novel antifungal agent that exerts antifungal activity by inhibiting glycosylphosphatidylinositol anchor biosynthesis. Although the mechanisms of resistance of species to manogepix have been reported previously, those of are yet to be studied.
View Article and Find Full Text PDFTechnological Improvement of Brined Black Table Olives Processed Using Two-Phase and Single-Phase Methods Under Slight CO Pressure and Low Salt Content.
Foods
November 2024
Department of Agricultural, Environmental and Food Sciences, University of Molise, Via de Sanctis, I-86100 Campobasso, Italy.
The aim of this work was to study the fermentation of black table olives under slightly pressurized CO (spCO). The olives were marinated in brine with a low salt content and processed using both the traditional two-phase method and a new single-phase method. SpCO is a new technical tool, positively tested in previous studies on the production of low-salt table olive, as a third barrier to microbial growth in brine.
View Article and Find Full Text PDFInvestigating the association between Candida albicans and early childhood dental caries: A comprehensive systematic review and meta-analysis.
PLoS One
December 2024
Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Early childhood caries (ECC) is a significant public health concern affecting children globally. Recent studies suggest a potential association between the presence of Candida albicans (C. albicans) in the oral cavity and the risk of ECC, but findings have been inconsistent.
View Article and Find Full Text PDFRiverine mycobiome dynamics: From South African tributaries to laboratory bioreactors.
Mycology
January 2024
Department of Microbiology, University of Stellenbosch, Stellenbosch, South Africa.
Riverine fungi have the capacity for both pathogenicity, pertinent for countries with elevated immunosuppressed individuals, and bioremediation potential. The purpose was (i) to screen for the presence of clinically relevant riverine fungi and associations with anthropogenic influence, and (ii) the acclimatisation of environmental communities toward potential bioremediation application. Communities were harvested from polluted rivers in Stellenbosch, South Africa, and mycobiomes characterised by high-throughput amplicon sequencing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!