AI Article Synopsis
- Breast cancer is the second leading cause of cancer-related deaths, and prognostic factors like HER-2 and estrogen receptor (ER) are important for understanding treatment outcomes.* -
- A study analyzed 2000 pathological samples from patients at the Cancer Institute of Tehran, revealing HER-2 was present in 58.5% of cases and most cases were invasive ductal carcinoma (82.2%).* -
- The results indicated a significant prevalence of HER-2 and P53 positivity in patients who were typically in the perimenopausal age group (46-55 years), emphasizing the need for targeted breast cancer screening in this demographic.*
Article Abstract
Prognostic factors are in interest for breast cancer as the second cause of malignancy deaths. Some have predictive values as human epidermal growth factor receptor-2 (HER-2) and estrogen receptor (ER). To access the incidence of HER2 and its relations to other factors, like age, pathology, ER, progesterone receptor (PR), and P53, 2000 pathologic blocks from 2750 total samples have been selected from 2011 to 2013 in Cancer Institute of Tehran. Incidence of HER2, ER, PR, and P53 was; 58.5%, 33.4%, 43.3%, and 65.4%, respectively. Invasive ductal carcinoma was the most pathologic type (82.2%) and 60%-70% positive HER2 and P53 had negative ER and PR (poor prognosis). The peak age of incidence of breast cancer was perimenopausal age group (46-55 years). Our cases had more positive HER2 and P53 and less positive PR and ER compared to other studies. High perimenopausal incidence as another finding assures the importance of breast cancer screening in these age groups.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244923 | PMC |
| http://dx.doi.org/10.1155/2014/564308 | DOI Listing |
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