AI Article Synopsis
- This study investigated how Zishenpingchan granule affects neurobehavioral symptoms and dopamine receptor activity in rats experiencing levodopa-induced dyskinesias (LID).
- Three groups of rats were set up: a normal control group, an LID model group, and a group receiving traditional Chinese medicine (TCM) treatment for four weeks.
- Findings suggested that LID is primarily caused by excessive activation of the dopamine D1 receptor and inhibition of the D2 receptor, with TCM treatment improving symptoms by increasing the gene expression of the dopamine D2 receptor.
Article Abstract
This study was performed to observe the effects of Zishenpingchan granule on neurobehavioral manifestations and the activity and gene expression of striatal dopamine D1 and D2 receptors of rats with levodopa-induced dyskinesias (LID). We established normal control group, LID model group, and TCM intervention group. Each group received treatment for 4 weeks. Artificial neural network (ANN) was applied to excavate the main factor influencing variation in neurobehavioral manifestations of rats with LID. The results showed that overactivation in direct pathway mediated by dopamine D1 receptor and overinhibition in indirect pathway mediated by dopamine D2 receptor may be the main mechanism of LID. TCM increased the efficacy time of LD to ameliorate LID symptoms effectively mainly by upregulating dopamine D2 receptor gene expression.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247981 | PMC |
| http://dx.doi.org/10.1155/2014/342506 | DOI Listing |
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