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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235363 | PMC |
| http://dx.doi.org/10.3389/fimmu.2014.00594 | DOI Listing |
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Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner.
Neuroimage
January 2025
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address:
Article Synopsis
- Sepsis leads to systemic immune issues and organ failure, often resulting in severe brain disability, with young females showing better recovery than males.
- Using a mouse model, researchers found that after experiencing sepsis, both male and female mice showed weight regain and reduced gut microbiome diversity, but males displayed more significant immune changes and brain inflammation.
- fMRI analysis highlighted that while both sexes experienced similar changes in certain brain areas, male mice had altered connectivity patterns suggesting a delayed recovery process compared to females, indicating a complex, sex-dependent response to sepsis.
Temporal therapy utilizing exosomes derived from M2 macrophages demonstrates enhanced efficacy in alleviating neuropathic pain in diabetic rats.
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January 2025
School of Anesthesia, Shanxi Medical University, Shanxi, China.
Background: Diabetic pain patients have increased pain at night. Exosomes can relieve neuropathic pain. This study aimed to investigate the efficacy of exosome administration at different time points in relieving diabetic neuropathic pain (DNP) in rats.
View Article and Find Full Text PDFTranscriptional signature of a hypersensitive glucocorticoid receptor variant in the neuroendocrine system suggests enhanced vulnerability to brain disorders.
Brain Behav Immun
February 2025
Competence Field Genetics and Genomics, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
The natural substitution Ala610Val in the porcine glucocorticoid receptor (GR) leads to a profound compensatory downregulation of the hypothalamic-pituitary-adrenal (HPA) axis in early ontogeny. In this study, we leveraged this unique animal model to explore mechanisms of HPA axis regulation and consequences of its genetically-based persistent hypoactivity. To this end, we examined transcriptional signature of GR in the hypothalamus, hippocampus, amygdala and adrenal gland in resting conditions (i.
View Article and Find Full Text PDFTREM1-Microglia crosstalk: Neurocognitive disorders.
Brain Res Bull
January 2025
Early Clinical Research Ward, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China. Electronic address:
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- Neurocognitive Disorders (NCDs) impact cognitive abilities like memory and problem-solving, typically arising from central nervous system issues.
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Time-dependent phenotypical changes of microglia drive alterations in hippocampal synaptic transmission in acute slices.
Front Cell Neurosci
November 2024
Department of Physiology and Pharmacology, Sapienza University, Laboratory Affiliated to Institute Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.
Article Synopsis
- Microglia play a crucial role in regulating synaptic function in the brain, but their behavior in acute brain slices may be influenced by the slicing and maintenance process.
- In this study, researchers found that after 4 hours of slicing, microglia show morphological and functional changes, including becoming more reactive and altering their signaling capabilities.
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