A sensitive and selective electrochemical sensor based on molecular imprinting polymers grafted graphene (MIPs-G) was developed for simultaneous measurement of 4, 4-methylene diphenylamine (MDA) and aniline by differential pulse voltammetry (DPV). MIPs-G was synthesized via free radical polymerization reaction using MDA and 4-vinyl pyridine as template molecule and functional monomer respectively. The obtained nanocomposites were characterized by transmission electron microscope, scanning electron microscope, Fourier transform infrared spectrometry, Raman spectroscopy and thermal gravimetric analysis. After removal template molecules, MIPs-G was used as electrode material for aromatic amines measurements. Due to the high binding affinity towards MDA and the π-π interaction with aniline, the MIPs-G based electrochemical sensor can be used for simultaneous detection of MDA and aniline by DPV. Under the optimized condition, the oxidation potentials for MDA and aniline were observed at 0.62 and 0.72 V, respectively. Moreover, MIPs-G modified glassy carbon electrode shows linear response towards MDA and aniline simultaneously over the range of 1.0 to 15 μM. The MIPs-G based electrochemical sensor has been applied for simultaneous measurement of MDA and aniline in plastic tableware.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.talanta.2014.09.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Design and Development of Novel Hybrids Based on Pyrrolo[2,1-f][1,2,4]Triazine and 1-(Methylpiperidin-4-yl) Aniline-Based Analogs: Exploring the Utility as Anticancer Agents via MERTK Inhibition.
Chem Biol Drug Des
December 2024
Department of Chemistry, Bharatiya Vidya Bhavan College, Chowpatty, Mumbai University, Mumbai, India.
Article Synopsis
- * Researchers designed new drug candidates by hybridizing two pharmacophoric systems, leading to the creation of novel molecules (1K1-1K5) using a multi-step synthesis method.
- * The new compounds showed promising effectiveness in inhibiting MERTK, particularly IK5, which had low IC values against various cancer cell lines, and demonstrated good stability and clearance profiles for further testing.
External quality assurance schemes (EQUASs) and interlaboratory comparison investigations (ICIs) for the human biomonitoring of aromatic amines in urine as part of the quality assurance programme under HBM4EU.
Anal Methods
December 2024
Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Henkestraße 9-11, 91054 Erlangen, Germany.
Exposure to aromatic amines may occur tobacco smoke, hair dyes or tattoo inks, but also in the workplace during certain manufacturing processes. As some aromatic amines are known or suspected carcinogens, human biomonitoring (HBM) is essential to assess their exposure. Aromatic amines were among the selected chemicals in HBM4EU, a European-wide project to harmonise and advance HBM within 30 European countries.
View Article and Find Full Text PDFNon-analgesic effects of opioids: Topical application of Eucerin-based ointment containing opium on the healing process of thermal skin damage in rats.
PLoS One
November 2024
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran.
Article Synopsis
- The study evaluated the effectiveness of Eucerin-based ointments with varying opium concentrations (0.05%, 0.5%, 5%) compared to the standard silver sulfadiazine treatment in treating burn injuries in rats.
- Results indicated that lower concentrations of opium significantly improved wound healing compared to silver sulfadiazine, with the 0.05% opium ointment outperforming it.
- The mixed-group treatment, combining 0.05% opium with silver sulfadiazine, also showed enhanced healing effects, indicating potential benefits of opium in burn treatment.
Exploring the impact of mitochondrial-targeting anthelmintic agents with GLUT1 inhibitor BAY-876 on breast cancer cell metabolism.
BMC Cancer
November 2024
Integrated Biosciences Graduate Program, University of Minnesota, 1035 Kirby Drive, Duluth, MN, 55812, USA.
Background: Cancer cells alter their metabolic phenotypes with nutritional change. Single agent approaches targeting mitochondrial metabolism in cancer have failed due to either dose limiting off target toxicities, or lack of significant efficacy in vivo. To mitigate these clinical challenges, we investigated the potential utility of repurposing FDA approved mitochondrial targeting anthelmintic agents, niclosamide, IMD-0354 and pyrvinium pamoate, to be combined with GLUT1 inhibitor BAY-876 to enhance the inhibitory capacity of the major metabolic phenotypes exhibited by tumors.
View Article and Find Full Text PDFOTUB1 regulation of ferroptosis and the protective role of ferrostatin-1 in lupus nephritis.
Cell Death Dis
November 2024
Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, P. R. China.
Lupus nephritis (LN) is a prevalent and severe manifestation of systemic lupus erythematosus (SLE), leading to significant morbidity and mortality. OTUB1, a deubiquitinating enzyme, has emerged as a potential therapeutic target due to its role in cellular protection and regulation of ferroptosis, a form of cell death linked to LN. Our study revealed significantly reduced OTUB1 expression in the glomeruli of LN patients and podocytes, correlated with disease severity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!