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Expert Judgment Supporting a Bayesian Network to Model the Survival of Pancreatic Cancer Patients.
Cancers (Basel)
January 2025
Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, 35122 Padova, Italy.
: Pancreatic cancer is known for its poor prognosis. The most effective treatment combines surgery with peri-operative chemotherapy. Current prognostic tools are designed to predict patient outcomes and inform treatment decisions based on collected data.
View Article and Find Full Text PDFPhloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice.
Int J Pharm X
June 2025
Technology of Radiology and Medical Imaging Department, Faculty of Applied Health Science Technology, October 6 University, Egypt.
Objectives: Colorectal cancer is the third most common cancer worldwide, accounting for approximately 10 % of all cancer cases. It is also the second leading cause of cancer-related deaths globally. Phloretin is a natural compound found in apples and other fruits.
View Article and Find Full Text PDFPrognostic impact and reasons for variability by tumor location in gastric cancer.
World J Gastroenterol
November 2024
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou 310022, Zhejiang Province, China.
Background: Gastric cancer (GC) is a highly prevalent gastrointestinal tract tumor. Several trials have demonstrated that the location of GC can affect patient prognosis. However, the factors determining tumor location remain unclear.
View Article and Find Full Text PDFA Case of Porcelain Gallbladder Showing High Levels of CA19-9.
Cureus
October 2024
Department of Surgery, Kitakyushu City Yahata Hospital, Kitakyushu, JPN.
Article Synopsis
- Porcelain gallbladder is a rare condition marked by calcification of the gallbladder wall, increasing the risk of gallbladder cancer and leading to high levels of the tumor marker CA19-9.
- A case study presented a 60-year-old woman with abdominal pain and nausea, where imaging revealed porcelain gallbladder and common bile duct stones; her CA19-9 levels were extremely elevated after stone removal.
- Post-surgery, histopathology showed no cancer but inflammation and calcification, and CA19-9 levels normalized, emphasizing that benign conditions can elevate CA19-9 and the importance of accurate diagnosis.
Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer.
Mol Oncol
November 2024
Department of Pathology, Division of Laboratory Medicine, Oslo University Hospital, Norway.
Neoadjuvant chemotherapy (NAT) is increasingly used for the treatment of non-metastatic pancreatic ductal adenocarcinoma (PDAC) and is established as a standard of care for borderline resectable and locally advanced PDAC. However, full exploitation of its clinical benefits is limited by the lack of biomarkers that assess treatment response. To address this unmet need, global metabolomic profiling was performed on tumor tissue and paired serum samples from patients with treatment-naïve (TN; n = 18) and neoadjuvant leucovorin calcium (folinic acid), fluorouracil, irinotecan hydrochloride and oxaliplatin (FOLFIRINOX)-treated (NAT; n = 17) PDAC using liquid chromatography mass spectrometry.
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