AI Article Synopsis
- Trefoil factors (TFF) and mucins, produced by goblet cells, are important for gut barrier function during infections and inflammation, particularly in pediatric inflammatory bowel diseases (IBD) like Crohn's disease (CD) and ulcerative colitis (UC).
- In biopsies from children, TFF2 mRNA levels were lower in inflamed tissues in CD and UC compared to healthy controls, while non-inflamed tissues showed higher TFF2 levels in CD.
- The research indicates notable changes in mucin and TFF gene expression in children with IBD, suggesting they could play a role in mucosal healing and may serve as biomarkers for disease progression, warranting further investigation.
Article Abstract
In the intestinal mucosa trefoil factors (TFF) and mucins (Muc) - primarily produced by goblet cells - are thought to play a major role in providing barrier function during infection and inflammation. To investigate their role in pediatric Crohn's disease (CD) and ulcerative colitis (UC) we obtained mucosal biopsies of children with CD, UC and healthy controls and analyzed genetic expression. Levels of TFF2 mRNA were lower in inflamed mucosal samples (terminal ileum (TI) and duodenum) of children with CD, but higher in non-inflamed mucosal samples when compared to healthy controls (p < 0.05). Similarly, TFF2 levels in the TI were significantly lower in inflamed UC tissue. Adjustment for goblet cell density revealed slightly less marked, yet significantly different gene expression in IBD and controls. Furthermore, TI expression of TFF2 and Muc2 was inversely correlated with interleukin-8 expression in CD (p = 0.027). In Summary, our data demonstrate significant changes in Muc and TFF mRNA expression in pediatric patients with IBD suggesting a role in mucosal healing. Further studies are needed to elucidate a potential use as biomarkers for disease progression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256710 | PMC |
| http://dx.doi.org/10.1038/srep07343 | DOI Listing |
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