Past experience resets behavior: CaMK takes the heat.

Neuron

Life Sciences Institute and Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Published: December 2014

How past experiences reshape behavior is not well understood. In this issue, two studies (Schild et al., 2014; Yu et al., 2014) dissected the molecular mechanisms underlying experience-dependent plasticity in thermosensory behavior. They show that Ca(2+)/calmodulin-dependent kinase I (CaMKI) regulates thermal preferences according to past experience.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301849PMC
http://dx.doi.org/10.1016/j.neuron.2014.11.014DOI Listing

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