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Intestinal Osteosarcoma with Liver Metastasis in a Dog with a History of Recurrent Cotton-Based Toy Fragment Ingestion.
Vet Sci
December 2024
Department of Anatomic Pathology, Faculty of Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Canine extraskeletal osteosarcomas are mesenchymal, osteoid producing tumors that can arise in soft tissues without initial involvement of the bones. An 8-year-old intact male Beagle dog presented with anorexia, abdominal pain, intermittent vomiting and melena. The patient had a history of recurrent ingestion of cotton based-toy fragments, but no prior surgical procedures involving the abdominal cavity.
View Article and Find Full Text PDFOTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway.
J Exp Clin Cancer Res
December 2024
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Osteosarcoma (OS), the most prevalent primary malignant bone tumor in children and adolescents, arises from bone-forming mesenchymal cells. Despite advancements in surgical resection and neoadjuvant chemotherapy (cisplatin, doxorubicin, and methotrexate), chemotherapy resistance remains a significant challenge, leading to poor survival rates in patients with metastatic or recurrent OS.
Methods: In this study, we focused on the role of OTULIN, a key linear deubiquitinating enzyme, in OS chemoresistance.
A Rare Case of Cementoblastoma of the Second Right Maxillary Premolar in a 30-Year-Old Man.
Cureus
November 2024
Department of Pediatric Dentistry, Medical University "Prof. Dr. Paraskev Stoyanov", Varna, BGR.
Cementoblastoma is a benign odontogenic mesenchymal tumor characterized by cementum production. Cementoblastoma is considered a relatively rare neoplasm with a predilection to the posterior region of the mandible. The main clinical differential diagnoses include hypercementosis, cemento-osseous dysplasia, condensing osteitis, idiopathic osteosclerosis, osteoblastoma, odontoma, and osteosarcoma.
View Article and Find Full Text PDFPrimary Ewing's Sarcoma affecting the Central Nervous System: A single-center experience and Narrative review.
Childs Nerv Syst
December 2024
Department of Neurosurgery, All India Institute of Medical Sciences, CNC, Room No 720, New Delhi, India.
Background And Objectives: Ewing's sarcoma (EWS) is a malignant round-cell tumor arising from the bone and soft tissue. It is a disease of children and young adults. EWS affecting the central nervous system (cranial and spinal column) is relatively rare with an annual incidence of approximately one case per million in the Western population.
View Article and Find Full Text PDFMetastatic dedifferentiated liposarcoma of the mediastinum with osteosarcomatous differentiation: A case report.
Medicine (Baltimore)
December 2024
Department of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Article Synopsis
- Liposarcoma is a rare malignant tumor that can occur in the mediastinum, and most existing information comes from scattered reports rather than extensive studies.
- A 51-year-old man presented with respiratory symptoms and was found to have a large mediastinal mass that was misidentified as a teratoma; after surgery, he was diagnosed with dedifferentiated liposarcoma.
- Despite surgical intervention and chemotherapy, the patient experienced rapid recurrence and ultimately died four months post-surgery, highlighting the need for correct diagnosis and treatment strategies for this aggressive condition.*
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