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Article Abstract
The protein encoded by ORF9 is essential for varicella-zoster virus (VZV) replication. Previous studies documented its presence in the trans-Golgi network and its involvement in secondary envelopment. In this work, we deleted the ORF9p acidic cluster, destroying its interaction with ORF47p, and this resulted in a nuclear accumulation of both proteins. This phenotype results in an accumulation of primary enveloped capsids in the perinuclear space, reflecting a capsid de-envelopment defect.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338894 | PMC |
| http://dx.doi.org/10.1128/JVI.03215-14 | DOI Listing |
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