AI Article Synopsis
- Four sesquiterpenes were isolated from Curcuma xanthorrhiza, including furanodiene and 13-hydroxygermacrone, marking the first isolation of these compounds from the plant.
- The chemical structures of these compounds were identified using advanced techniques like nuclear magnetic resonance and mass spectrometry.
- Compounds germacrone and 13-hydroxygermacrone showed the ability to inhibit the UVB-induced increase of specific mRNA and protein levels related to skin damage in human skin cells, showing effectiveness in a dose-dependent manner.
Article Abstract
Four sesquiterpenes were isolated from the rhizome of Curcuma xanthorrhiza Roxb.: furanodiene (1), germacrone (2), furanodienone (3), and 13-hydroxygermacrone (4). Importantly, this was the first time compounds 1 and 4 were isolated from this plant. The chemical structures of these compounds were determined using 1D- and 2D-nuclear magnetic resonance, infrared spectroscopy, and electron ionization mass spectrometry analyses. Among the isolated compounds, compounds 2 and 4 inhibited UVB-induced upregulation of the mRNA and protein expression levels of MMP-1, MMP-2, and MMP-3 in human keratinocytes (HaCaT). Moreover, this upregulation occurred in a dose-dependent manner over the range of 1-10 μM for each compound.
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| http://dx.doi.org/10.1007/s12272-014-0525-z | DOI Listing |
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