The article reviews our recent data on the mechanisms of corticotropin-releasing factor (CRF) effect on the somatic pain sensitivity. The involvement of opioid and glucocorticoid receptors and CRF receptors of type 2 in analgesic effect induced by systemic CRF was studied in rats. According to the data obtained CRF receptors of type 2 are involved in CRF-induced analgesia whereas CRF-induced analgesic effect may be manifested in opioid-dependent and opioid-independent forms that apparently depend on pain stimulus and anesthesia. Opioid-independent form of anaIgesia may be provided by glucocorticoids.
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