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Impact of sarcopenic obesity on postoperative outcomes in patients with oesophago-gastric cancer: A systematic review and meta-analysis.
World J Surg
December 2024
Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, Tokyo, Japan.
Background: We elucidated the influence of sarcopenic obesity on postoperative outcomes in patients with oesophago-gastric cancer.
Methods: We conducted a systematic search on MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, the World Health Organization International Clinical Trials Platform Search Portal, and ClinicalTrials.gov to identify observational studies published from their inception to September 26, 2024.
Long-term results of laparoscopic Heller-Dor for esophageal-gastric junction outflow obstruction: a prospective comparative study.
Int J Surg
December 2024
Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, School of Medicine, Padova, Italy.
Background: The aim of this prospective, controlled study was to assess the 5-year follow-up of Laparoscopic Heller-Dor (LHD) in patients with esophago-gastric junction outflow obstruction (EGJOO), compared with achalasia patients (ACH). The management of EGJOO reflects the experience gained with esophageal achalasia, for which LHD has been proven to be an effective long-term treatment. Prospective long-term results of LHD in EGJOO patients are still lacking.
View Article and Find Full Text PDFPre-Surgical Endoscopic Biopsies Are Representative of Esophageal and Esophago-Gastric Junction Adenocarcinoma Histologic Classes and Survival Risk.
Cancers (Basel)
December 2024
Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, 16132 Genoa, Italy.
The Esophageal Adenocarcinoma Study Group Europe (EACSGE) recently proposed a granular histologic classification of esophageal-esophago-gastric junctional adenocarcinomas (EA-EGJAs) based on the study of naïve surgically resected specimens that, when combined with the pTNM stage, is an efficient indicator of prognosis, molecular events, and response to treatment. In this study, we compared histologic classes of endoscopic biopsies taken before surgical resection with those of the surgical specimen, to evaluate the potential of the EACSGE classification at the initial diagnostic workup. A total of 106 EA-EGJA cases with available endoscopic biopsies and matched surgical resection specimens were retrieved from five Italian institutions.
View Article and Find Full Text PDFExpression of therapy target molecules in esophagogastric junction and Barrett's adenocarcinoma.
Gastric Cancer
December 2024
Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Article Synopsis
- This study investigates the presence of therapeutic target molecules in esophagogastric junction (EGJ) and Barrett's adenocarcinomas, focusing on 114 non-Barrett's and 30 Barrett's cases.
- Various molecular markers were assessed, revealing that a majority of EGJ (81.6%) and Barrett's (86.7%) adenocarcinomas expressed at least one target molecule, with PD-L1 having a significant correlation with better survival rates.
- The findings suggest that most patients with EGJ and Barrett's adenocarcinoma could benefit from molecular targeted therapy, highlighting the importance of tailored treatments based on individual molecular profiles for improved outcomes.
REsolution of Symptoms afTer Oesophago-gastric cancer REsection delphi (RESTOREd)-standardizing the definition, investigation and management of gastrointestinal symptoms and conditions after surgery.
Br J Surg
November 2024
Department of Gastroenterology, United Lincolnshire Hospitals NHS Trust, Lincoln, UK.
Background: Oesophago-gastric cancer surgery negatively affects quality of life with a high postoperative symptom burden. Several conditions that may be diagnosed and treated after surgery are recognised. However, consensus regarding their definition and management is lacking.
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