AI Article Synopsis
- The study investigates how nesfatin-1, a neuroendocrine peptide, relates to food intake, body composition, and resting metabolic rate (RMR) in obese individuals.
- Researchers analyzed data from 96 obese subjects, assessing body composition, RMR, and blood samples to measure nesfatin-1 and PPARγ levels.
- Results show a significant correlation between nesfatin-1 levels and body fat percentage, particularly strong in morbidly obese subjects, suggesting a link between these factors in regulating metabolism and energy homeostasis.
Article Abstract
Aims: Nesfatin-1 identified neuroendocrine peptide is involved in regulation of homeostasis via modulation of metabolism, energy homeostasis and food intake. We aimed to investigate the associations of circulating nesfatin-1 level with food intake, body composition and resting metabolic rate (RMR) and also examine the correlation between circulating peroxisome proliferator-activated receptor gamma (PPARγ) and nesfatin-1 levels in obese and morbid obese subjects.
Methods: A total of 96 obese subjects (including 18 morbid obese subjects) were participated in the current cross-sectional study. We assessed the body composition with the use of Body Composition Analyzer. RMR was measured by means of the MetaCheck™, an instrument designed to measure RMR using indirect calorimetry. All baseline blood samples were obtained following an overnight fasting. Plasma concentrations of nesfatin-1 and circulating PPARγ were measured with the use of an ELISA method. Statistical analyses were performed using SPSS.
Results: We found significant associations between fat percent and circulating nesfatin-1 in obese and morbid obese subjects. There was main association between circulating nesfatin-1 and PPARγ concentration in obese subjects and it was more strong association in morbid obese participants. There was marginally significant differences between percent predicted RMR between different categorized nesfatin-1 levels. There were also higher intakes of calorie, carbohydrate and protein in obese group who had lower concentration of nesfatin-1.
Conclusions: Our data indicated the fat percent as main determinant factor in circulating nesfatin-1 level. It appears nesfatin-1 and PPARγ might be concurrently involved in adipogenesis pathway.
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| http://dx.doi.org/10.1016/j.dsx.2014.04.010 | DOI Listing |
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