Controversies in the psychopharmacology of bipolar disorder.

J Clin Psychiatry

From the Department of Psychiatry, George Washington University School of Medicine, Washington, DC, and the Bipolar Collaborative Network, Bethesda, Maryland.

Published: November 2014

AI Article Synopsis

  • Few studies focus on how doctors decide on mood stabilizers or antipsychotics for bipolar disorder patients, despite the ongoing use of traditional antidepressants with little evidence of their effectiveness.
  • The article highlights pharmacological principles that support the evidence-based approach to using mood stabilizers and antipsychotics.
  • It reviews important aspects like choosing the right therapies for ongoing treatment, decision-making strategies when there's only a partial response to treatment, the use of combination therapies, and weighing the benefits and risks when treating bipolar depression.

Article Abstract

Few studies have examined the decision-making process for selecting a mood stabilizer or antipsychotic for patients with bipolar disorder. Despite a lack of evidence regarding their efficacy, conventional unimodal antidepressants continue to be used in bipolar treatment regimens. This article examines pharmacologic principles that can facilitate the evidence-based use of mood stabilizers and antipsychotics in patients with bipolar disorder. Choosing therapies for the maintenance of bipolar disorder, clinical decision making upon observation of a partial response, the use of combination therapies, and benefit/harm considerations when choosing a treatment for bipolar depression will be reviewed.

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Source
http://dx.doi.org/10.4088/JCP.13095tx2cjDOI Listing

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