AI Article Synopsis
- Okadaic acid can bind to both particulate and cytosolic fractions in various mouse tissues including skin, brain, lung, and colon, indicating its potential role in tumor promotion.
- The study found that the binding affinity (KD value) for receptors in mouse skin's particulate fraction was 21.7 nM, while the cytosolic fraction had a much higher affinity at 1.0 nM.
- The binding of okadaic acid to the particulate fraction was inhibited in a dose-dependent manner by okadaic acid itself, unlike its inactive counterpart or other known tumor promoters, suggesting it may involve a unique receptor pathway for tumor promotion.
Article Abstract
The tumor promoter okadaic acid binds specifically to a particulate as well as a cytosolic fraction of various mouse tissues, e.g., skin, brain, lung and colon. The KD value was 21.7 nM for receptors in the particulate fraction and 1.0 nM for those in the cytosolic fraction of mouse skin. The specific binding of [3H]okadaic acid to the particulate fraction of mouse skin was inhibited dose-dependently by okadaic acid, but not okadaic acid tetramethyl ether, an inactive compound, or by other tumor promoters, such as 12-O-tetradecanoylphorbol-13-acetate and teleocidin. The results suggest a new pathway of tumor promotion mediated through the okadaic acid receptor(s).
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| http://dx.doi.org/10.1016/0014-5793(89)80807-5 | DOI Listing |
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