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Pullulan dialdehyde cross-linked dual-action adhesive with high adhesion to lung tissue and the capability of pH-responsive drug release.
Carbohydr Polym
January 2025
School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University, Wuxi 214122, China. Electronic address:
To address the main challenges for thoracoscopic lung cancer surgery, including persistent pulmonary air leaks and cancer recurrence, this study developed an in-situ adhesive that can effectively adhere to the lung and release the anticancer drug in response to pH. The adhesive was formulated using hydrophobically modified cold-water fish skin gelatin (hm-CFG) and cross-linking agent pullulan dialdehyde (PDA), in which succinic dihydrazide-modified doxorubicin (SDH-DOX) can be incorporated. Utilizing PDA could improve both cohesion and interfacial adhesion, while also offering drug-loading sites through the aldehyde groups that were not involved in cross-linking.
View Article and Find Full Text PDFEnhanced tumor targeting and penetration of fluorophores via iRGD peptide conjugation: a strategy for the precision targeting of lung cancer.
Transl Lung Cancer Res
August 2024
Department of Thoracic Surgery, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Background: Accurate real-time tumor delineation is essential for achieving curative resection (R0 resection) during non-small cell lung cancer (NSCLC) surgery. The unique characteristics of lung tissue structure significantly challenge the use of video-assisted thoracoscopic surgery in the identification of lung nodules. This difficulty often results in an inability to discern the margins of lung nodules, necessitating either an expansion of the resection scope, or a transition to open surgery.
View Article and Find Full Text PDFOutcomes of mobilization in the first hour following uniportal video-assisted thoracoscopic surgery for primary spontaneous pneumothorax.
Kardiochir Torakochirurgia Pol
March 2024
Department of Thoracic Surgery, Istinye University, Istanbul, Turkey.
Introduction: Although primary spontaneous pneumothorax is a common disease in young adults, each thoracic surgery department performs different procedures for its management.
Aim: The optimal time of postoperative mobilization is not yet standardized in lung surgery.
Material And Methods: This study included male patients with a primary spontaneous pneumothorax who underwent wedge resection of the upper lobe of the lungs via uniportal video-assisted thoracoscopic surgery.
Comparison between use of a pleural drainage system with flutter valve and a conventional water-seal drainage system after lung resection: a randomized prospective study.
Sao Paulo Med J
April 2024
MD, PhD. Neurosurgeon, Head of the Cerebral Hydrodynamics Group, Functional Neurosurgery Division, Institute of Psychiatry, Hospital das Clínicas, Faculty of Medicine, Universidade de São Paulo (USP), São Paulo (SP), Brazil.
Background: There is still a debate regarding the most appropriate pleural collector model to ensure a short hospital stay and minimum complications.
Objectives: To study aimed to compare the time of air leak, time to drain removal, and length of hospital stay between a standard water-seal drainage system and a pleural collector system with a unidirectional flutter valve and rigid chamber.
Design And Setting: A randomized prospective clinical trial was conducted at a high-complexity hospital in São Paulo, Brazil.
Zero-leak prediction during major lung resection aiming for minimal chest drainage duration: a retrospective analysis.
J Cardiothorac Surg
March 2024
Department of Thoracic Surgery, St Luke's International Hospital, Akashi-Cho 9-1, Chuo-ku, Tokyo, 104-8560, Japan.
Background: Early chest tube removal should be considered to enhance recovery after surgery. The current study aimed to provide a predictive algorithm for air leak episodes (ALE) and to create a knowledge base for early chest tube removal.
Methods: This retrospective study enrolled patients who underwent thoracoscopic anatomical pulmonary resections in our unit.
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