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Rewiring cancer: 3D genome determinants of cancer hallmarks.
Curr Opin Genet Dev
January 2025
Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA; Broad Institute, Cambridge, MA, USA; Department of Pathology, Harvard Medical School, Boston, MA, USA. Electronic address:
In modern cancer biology, Hanahan and Weinberg's classic depiction of the Hallmarks of Cancer serves as a heuristic for understanding malignant phenotypes [1]. Genetic determinants of these phenotypes promote cancer induction and progression, and these mutations drive current approaches to understanding and treating cancer. Meanwhile, for over a century, pathologists have noted that profound alterations of nuclear structure accompany transformation, integrating these changes into diagnostic classifications (Figure 1).
View Article and Find Full Text PDFA Landscape of Cancer Initiation and Cancer Stem Cells.
Cancers (Basel)
January 2025
Laboratory of Cancer Stem Cell Engineering, Faculty of Interdisciplinary Science and Engineering of Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
Exposure to radiation and chemicals, oncogenic viruses, microbiomes, and inflammation are the major events of cancer initiation. DNA damage and chromosomal aberrations are classically considered the main causes of cancer. The recent idea of epigenetics is broadening the concept, including the suggestion that oncogenic virus infection disrupts various intracellular signaling cascades.
View Article and Find Full Text PDFSickle Cell Anemia and Inflammation: A Review of Stones and Landmarks Paving the Road in the Last 25 Years.
Hematol Rep
January 2025
Laboratory of Immunobiology and Immunogenetics, Post Graduation Program in Genetics and Molecular Biology (PPGBM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.
A quarter of a century ago, sickle cell disease (SCD) was mainly viewed as a typical genetic disease inherited as a classical Mendelian trait. Therefore, the main focus concerning SCD was on diagnosis, meaning, genotyping, and identification of homozygous and heterozygous individuals carrying the relevant HbS mutant allele. Nowadays, it is well established that sickle cell disease is indeed the result of homozygosis for the HbS variant, although this single feature is not capable of explaining the highly diverse clinical presentation of SCD.
View Article and Find Full Text PDFThis article traces the emergence and application of Max Weber's influential concept of charisma in his "Confucianism and Taoism" (1920) and "Politics as a Vocation" (1919), two texts that have not received much attention in the discussion of charisma. Through these texts, we learn to appreciate Weber's engagement with classical Chinese philosophy and the global composition of this key idea in the twentieth century.
View Article and Find Full Text PDFWater Quality and Kidney Health in Farming Communities.
S D Med
October 2024
Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
Since the turn of the century, there has been an increase in the frequency of chronic interstitial nephritis in agricultural communities. This is particularly evident in young farm workers from equatorial regions, where the prevalence of chronic kidney disease cannot be explained by classical risk determinants or exposure to heat stress alone. Potentially causal agents have included organic and inorganic drinking water contaminants.
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