Pyrrole alkaloids from the fruits of Morus alba.

Bioorg Med Chem Lett

College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea. Electronic address:

Published: December 2014

AI Article Synopsis

  • The study explored the fruits of Morus alba and identified seventeen pyrrole alkaloids, including five new ones named morroles B-F.
  • The structures of these new compounds were determined using spectroscopic methods.
  • Two of the isolated compounds showed significant inhibition of pancreatic lipase activity, suggesting potential health benefits.

Article Abstract

Phytochemical investigation of the fruits of Morus alba afforded seventeen pyrrole alkaloids including five new compounds. The structures of five new pyrrole alkaloids, named morroles B-F (4, 5, 7, 16 and 17), were determined on the basis of spectroscopic interpretations. 4-[Formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]butanoate (2) was synthesized by chemical reaction but first isolated from nature. Among isolated compounds, compounds 6 and 14 significantly inhibited pancreatic lipase activity.

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Source
http://dx.doi.org/10.1016/j.bmcl.2014.10.073DOI Listing

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