AI Article Synopsis
- Researchers explored the use of poly(lactic-co-glycolic acid) (PLGA) combined with multi-wall carbon nanotubes (MWNTs) to create electrically conducting scaffolds for skeletal muscle tissue engineering using electrospinning.
- The study characterized the physical properties of these composite fibers and found that the amount of MWNTs significantly influenced factors like fiber structure, strength, and electrical conductivity.
- Results showed that these scaffolds were compatible with C2C12 muscle cells, leading to improved cell growth and more mature muscle fiber formation compared to scaffolds made from only PLGA.
Article Abstract
Electrically conducting scaffolds have attracted tremendous attention in skeletal muscle tissue engineering. In this paper, poly(lactic-co-glycolic acid) (PLGA)/multi-wall carbon nanotubes (MWNTs) composite fibrous scaffolds were fabricated using the electrospinning technique. The physical properties of the composite fibers were characterized and proliferation and differentiation of C2C12 cells on these scaffolds were examined. It was found that the addition of MWNTs modulated the physical properties of PLGA fibers including morphology, fiber diameter, degradation, tensile strength and electrical conductivity, depending on the amount of MWNTs. These fibrous scaffolds were cytocompatible and supported the proliferation of C2C12 cells. Importantly, C2C12 cells showed more mature myotube formation on PLGA/MWNTs composite fibrous scaffolds compared to PLGA scaffolds. These results indicate that PLGA/MWNTs composite electrospun fibers have great potential in skeletal muscle tissue engineering.
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| http://dx.doi.org/10.1016/j.colsurfb.2014.10.041 | DOI Listing |
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