Our previous reports described the use of the Hyperbolic Dirac Net (HDN) as a method for probabilistic inference from medical data, and a proposed probabilistic medical Semantic Web (SW) language Q-UEL to provide that data. Rather like a traditional Bayes Net, that HDN provided estimates of joint and conditional probabilities, and was static, with no need for evolution due to "reasoning". Use of the SW will require, however, (a) at least the semantic triple with more elaborate relations than conditional ones, as seen in use of most verbs and prepositions, and (b) rules for logical, grammatical, and definitional manipulation that can generate changes in the inference net. Here is described the simple POPPER language for medical inference. It can be automatically written by Q-UEL, or by hand. Based on studies with our medical students, it is believed that a tool like this may help in medical education and that a physician unfamiliar with SW science can understand it. It is here used to explore the considerable challenges of assigning probabilities, and not least what the meaning and utility of inference net evolution would be for a physician.
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http://dx.doi.org/10.1016/j.compbiomed.2014.10.011 | DOI Listing |
PeerJ
October 2024
Department of Vector Disease Control and Prevention, Xi'an Center for Disease Control and Prevention, Xi'an, Shaanxi, China.
Background: Dengue, a mosquito-borne viral disease, has occurred in many cities in China, and it tends to spread to higher latitudes (Huang et al., 2023). Xi'an, situated in central-west China, has witnessed an increase imported cases in the past few years, raising concerns of local dengue transmission.
View Article and Find Full Text PDFBMC Public Health
October 2023
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou City, Zhejiang Province, China.
Dengue fever is one of the biggest threats to public health in China, causing huge disease burden and economic loss. Aedes-mosquito surveillance could be a cornerstone for predicting the risk of Aedes-borne diseases and evaluating the effect of vector management during diseases outbreaks. The human landing catch (HLC) method is regarded as the "gold standard" for catching Aedes mosquitoes, but it potentially exposes field professionals to vectors of known or unknown pathogens.
View Article and Find Full Text PDFMalar J
July 2023
Kasetsart University, 50 Thanon Ngamwongwan, Lat Yao, Chatuchak, Bangkok, 10900, Thailand.
Background: The mosquito landing rate measured by human landing catches (HLC) is the conventional endpoint used to evaluate the impact of vector control interventions on human-vector exposure. Non-exposure based alternatives to the HLC are desirable to minimize the risk of accidental mosquito bites. One such alternative is the human-baited double net trap (HDN), but the estimated personal protection of interventions using the HDN has not been compared to the efficacy estimated using HLC.
View Article and Find Full Text PDFRes Pract Thromb Haemost
February 2023
Department of Medicine I, Clinical Division of Hematology and Hemostaseology, Medical University of Vienna, Austria.
Background: Patients with cancer have an increased risk of developing venous thromboembolism. Neutrophils and neutrophil extracellular traps (NETs) reportedly influence the risk of cancer-associated thrombosis. Subpopulations of high and low-density neutrophils (HDN/LDN) are of specific interest, as they might have different functions in cancer patients.
View Article and Find Full Text PDFNature
November 2021
Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-negative breast cancer (TNBC). The extracellular matrix (ECM) contributes to immune exclusion. However, strategies to reduce ECM abundance are largely ineffective or generate undesired outcomes.
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