AI Article Synopsis
- Modern drug discovery relies on integrated resources for effective decision-making and facilitating new findings, with a focus on pressing questions in the pharmaceutical industry.
- The Open PHACTS Discovery Platform combines data about compounds, targets, pathways, and diseases to address complex drug discovery questions.
- The platform offers computational workflows that provide solutions to these questions and makes them available for the scientific community through myExperiment.
Article Abstract
Modern data-driven drug discovery requires integrated resources to support decision-making and enable new discoveries. The Open PHACTS Discovery Platform (http://dev.openphacts.org) was built to address this requirement by focusing on drug discovery questions that are of high priority to the pharmaceutical industry. Although complex, most of these frequently asked questions (FAQs) revolve around the combination of data concerning compounds, targets, pathways and diseases. Computational drug discovery using workflow tools and the integrated resources of Open PHACTS can deliver answers to most of these questions. Here, we report on a selection of workflows used for solving these use cases and discuss some of the research challenges. The workflows are accessible online from myExperiment (http://www.myexperiment.org) and are available for reuse by the scientific community.
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| http://dx.doi.org/10.1016/j.drudis.2014.11.006 | DOI Listing |
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