New 5'-glycyl derivatives of uridine containing fragments of varying lipophilicity were synthesized as analogues of natural peptidyl antibiotics. One of the studied compounds, 5'-O-(N-succinylglycyl)-2',3'-O-isopropylideneuridine (A4), showed moderate inhibition against 1,4-β-galactosyltransferase. However, additional studies showed that the observed inhibitory effect was due to binding to bovine serum albumin, which was used in assays as a stabilizer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bioorg.2014.11.001 | DOI Listing |
Publication Analysis
Top Keywords
5'-glycyl derivatives
8
derivatives uridine
8
synthesis biological
4
biological evaluation
4
evaluation 5'-glycyl
4
uridine inhibitors
4
inhibitors 14-β-galactosyltransferase
4
14-β-galactosyltransferase 5'-glycyl
4
uridine fragments
4
fragments varying
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!