AI Article Synopsis
- Diagnosis of Roseolovirus infections requires careful patient selection, sample choice, and testing methods.
- Recent advances like quantitative PCR can distinguish between HHV-6 species A and B, but the benefits of screening high-risk patients are still uncertain.
- Emerging techniques, such as digital PCR and reverse transcription qPCR, offer improved specificity and accuracy for diagnosing active infections despite challenges in result interpretation.
Article Abstract
Diagnosis of Roseolovirus infections mandates careful selection of patients, samples, and testing methods. We review advances in the field and highlight research priorities. Quantitative (q)PCR can accurately identify and distinguish between human herpesvirus 6 (HHV-6) species A and B. Whether screening of high-risk patients improves outcomes is unclear. Chromosomally integrated (ci)HHV-6 confounds test interpretation but can be ruled out with digital PCR. Reverse transcription qPCR may be a more specific and clinically applicable test for actively replicating Roseoloviruses, particularly among patients with ciHHV-6. Interpretation of Roseolovirus test results faces many challenges. However, careful application of refined and emerging diagnostic techniques will allow for increasingly accurate diagnosis of clinically significant infections and disease associations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573551 | PMC |
| http://dx.doi.org/10.1016/j.coviro.2014.09.014 | DOI Listing |
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